e.g. She upsets me when she doesn't think clearly and makes poor choices.
e.g. She is upset with her husband because he yet again forgot to buy groceries.
e.g. The cat upset the fishbowl, causing the water and all the fish to fall out.
e.g. An irregular sleep and work schedule can upset your work-life balance.
e.g. The country is dealing with some of the biggest political and economic upsets they have ever come across.
e.g. She has an upset stomach, possibly because of the sandwich she ate for lunch.
drive someone crazy / drive someone nuts
in a huff