e.g. He provided her with a substantial amount of cash to use in case of emergencies.
e.g. He fed the poor kid a substantial meal and gave him a jacket to wear in the cold.
e.g. A substantial tent that could not get knocked over even by harsh winds.
e.g. Human beings are substantial, spirits and souls are intangible.
e.g. They have substantial concerns about working with and obtaining stem cells.
e.g. He told a substantial lie that could get him trouble if anyone found out.