a disorder or condition that impairs the function of a living being and usually manifests in symptoms that are not a direct result of injury, and that make everyday function difficult or impossible;
e.g. Poor hygiene and routine health practices often result in the manifestation and spread of the completely preventable disease.
(noun)
a particular quality, idea, habit, inclination, etc., that is seen as negatively imparting a person or group;
e.g. The school's bad reputation was seen as a disease for the rest of the city.